fbpx
A sensible choice for veterinarians

Why trust Animora

Our mission

Animora’s mission is to improve pets’ health and well-being by providing innovative animal health products.

The values that permeate the company are reflected in our everyday work: our passion for animals motivates us to move the company forward, scientific research is central to our product development strategy, and commitment to our community is essential to us. Indeed, we are proud to renew our product donations to shelters each year and to educate the community about the importance of good dental hygiene in cats and dogs.

Our main concern

Periodontal disease

Periodontal disease is the most common infectious disease in pets. This disease refers to a group of inflammatory diseases caused by bacteria contained in dental plaque. Starting at the age of two, nearly 80% of dogs and 70% of cats have it [1]. The prevalence increases with age and is higher in small animals [2].

For treatment to be successful or for effective prevention against this disease, a multidimensional approach must be considered. Indeed, follow-up visits to the veterinarian, in addition to a rigorous home dental hygiene program, are essential. The knowledge and commitment of the owner as well as the co-operation of the animal are key factors for successful hygiene care [3].

[1] Niemiec, B. A., Veterinary Periodontology. 2013: Wiley-Blackwell. [2] Lund, E.M., et al., Health status and population characteristics of dogs and cats examined at private veterinary practices in the United States. J Am Vet Med Assoc, 1999. 214 (9): p. 1336-41. [3] Roudebush, P., E. Logan, and F.A. Hale, Evidence-based veterinary dentistry: a systematic review of homecare for prevention of periodontal disease in dogs and cats. J Vet Dent, 2005. 22(1): p. 6-15.

Methods of administration

This tasty product can be applied in several ways, taking a multi-step approach that ends with toothbrushing.

FLAGSHIP PRODUCT

cranberry
DENTAL GEL

Health Canada NN. G7J8
Veterinary Health Product

Claims

Cranberry Dental Gel improves oral health in dogs and cats by preventing bad breath and dental plaque buildup.

Characteristics

The texture of the dental gel has been optimized, making it sticky on the teeth and gums to increase contact time with the oral walls. Pets’ interest in the flavour was an important factor in the development of the product, helping to make the job of administering it as pleasant as possible. The animal can thus make a positive association with the dental gel and the owner will have an easier time maintaining their pet’s oral hygiene.

Precautions

Do not use in animals with kidney disease, unless directed by a veterinarian. Refrigerate after opening.

Active ingredient
Cranberries 30 mg/ml.
Ingredients
Water, vegetable glycerine, inulin, cellulose gum, citric acid, yeast extract, sodium chloride, sodium citrate, potassium sorbate, sodium diacetate.

Developed and manufactured in Canada. Enjoy the benefits of Quebec cranberries, all contained in a tube that was also produced in Quebec.

Scientifically proven

Mechanism of action
of cranberry

Proanthocyanidins (PACs) contained in cranberries are recognized as a natural weapon against periodontal diseases. The antibacterial, anti-adherence, anti-oxidant and anti-inflammatory properties of cranberry PACs have already been demonstrated in several studies.

Cranberry prevents periodontal pathogens from adhering to the surface of teeth to form plaque that causes most oral diseases. Thus, by preventing the formation of dental plaque, it is possible to prevent its transformation into tartar. In addition, these bacteria are also responsible for bad breath by secreting volatile sulfur compounds (VSCs). Cranberry reduces the virulence factors of periodontopathogenic bacteria, which makes bad bacteria less effective in their infection. It also has anti-inflammatory properties which reduces the gingivitis present and thus make the animal a little more comfortable. Modulation of host inflammation also reduces the destruction of tooth support tissues caused by the aggressive defense of the immune system.

Biofilm formation

Figure 1. Effect of the cranberry in Animora’s Dental Gel on the biofilm formation of two oral bacterial species found in cats and dogs.

Adhesion

Figure 2. Effect of the cranberry in the Animora’s Dental Gel on the adhesion to a hydroxyapatite surface of several bacterial species from the oral cavity of cats and dogs.

Antibacterial effect

The cranberry contained in Animora’s Dental Gel reduce biofilm formation by more than 50% for two bacterial species, Porphyromonas salivosa and Fusobacterium canifelinum. The concentrations used in the study were 2 and 4 mg/ml respectively, concentrations which are 15 and 7.5 times lower than that found in Cranberry Dental Gel.

The cranberry contained in the Animora’s Dental Gel reduces adhesion to a hydroxyapatite surface by up to 76% for several bacterial species from the oral cavity of cats and dogs. The concentration used was 2 mg/ml, i.e., a concentration 15 times lower than that found in Cranberry Dental Gel.

This study, carried out using the cranberry contained in the Animora’s Dental Gel, demonstrates its antibacterial potential. This effect has been observed both on the biofilm formation and on the adhesion to a hydroxyapatite surface of two bacterial genera from the oral cavity of cats and dogs.

Bacterial species belonging to the genera Porphyromonas and Fusobacterium are among the main oral pathogens in cats and dogs. Hydroxyapatite is the main component of teeth, making up 97% of enamel and 70% of dentin.

Anti-inflammatory effect

Cranberry Dental Gel significantly reduced IL6 production by 85% in a three-dimensional model of an oral mucosa equivalent under inflammatory stress.

Cranberry Dental Gel significantly reduced IL6 gene expression by 85% in a three-dimensional model of an oral mucosa equivalent under inflammatory stress.

This study, carried out using oral mucosa equivalents, demonstrates the anti-inflammatory potential of Cranberry Dental Gel. This effect was observed both on gene expression and on the secretion of pro-inflammatory cytokines.

IL6: Interleukin 6 is a pro-inflammatory cytokine involved in inflammatory and infectious responses. In chronic periodontitis, IL-6 is present in large quantities.

Biofilm formation

Figure 3. Effect of Cranberry Dental Gel on induced IL6 production in an oral mucosa equivalent.

Adhesion

Figure 4. Effect of Cranberry Dental Gel on induced IL6 gene expression in a mucosa equivalent. Results are expressed as relative gene expression values compared to untreated equivalents.