Proanthocyanidins (PACs) contained in cranberries are recognized as a natural weapon against periodontal diseases. The antibacterial, anti-adherence, anti-oxidant and anti-inflammatory properties of cranberry PACs have already been demonstrated in several studies.
Cranberry prevents periodontal disease bacteria from adhering to the surface of teeth with their fimbriae to form plaque that causes most oral diseases. Thus, by preventing the formation of dental plaque, it is possible to prevent its transformation into tartar. In addition, these bacteria are also responsible for bad breath by secreting volatile sulfur compounds (VSCs). Cranberry reduces the virulence factors of periodontopathogenic bacteria, which makes bad bacteria less effective in their infection. This small berry comes to play a big role at the level of the epithelial barrier of the gum. Indeed, it makes it possible to tighten the cells between them via the tight junctions to prevent the bacteria from infiltrating inside the gingival sulcus. It also has anti-inflammatory properties which reduces the gingivitis present and thus make the animal a little more comfortable. Modulation of host inflammation also reduces the destruction of tooth support tissues caused by the aggressive defense of the immune system.
The texture of the dental gel has been optimized to make it as sticky as possible on the teeth and gums of the animal to increase the contact time between the product and the oral walls of the animal. This texture makes it possible to administer the dental gel in several ways depending on whether the animal is cooperative or not. Its use with a toothbrush is the most effective method since there is the addition of a mechanical aspect. The appreciation of the taste by the animal has been an important element in the development of the dental gel to make its administration as pleasant as possible. The animal can thus make a good association with the dental gel and the owner will have more facility to do his oral hygiene.
Cranberry dental gel has been developed based on the results of several scientific papers that demonstrate the effectiveness of cranberry proanthocyanidins on the bacteria responsible for periodontal disease.
Here is a quick overview of scientific articles that demonstrate the effectiveness of cranberry extract and, more specifically, proanthocyanidins on several factors of periodontal disease.
J AgricFood Chem. 2012 Jun 13;60(23):5728-35. doi: 10.1021/jf203304v. Epub 2011 Nov 29.
Cranberry proanthocyanidins: natural weapons against periodontal diseases.
Feghali K, Feldman M, La VD, Santos J, Grenier D.
J Can Dent Assoc. 2010;76:a130.
Cranberry polyphenols: potential benefits for dental caries and periodontal disease.
Bonifait L, Grenier D.
J Indian Soc Periodontol. 2016 Sep-Oct;20(5):503-508. doi: 10.4103/jisp.jisp_302_16.
Inhibitory effect of cranberry extract on periodontopathogenic biofilm: An integrative review.
de Medeiros AKB, de Melo LA, Alves RAH, Barbosa GAS, de Lima KC, Porto Carreiro ADF.
J Indian Soc Periodontol. 2014 Mar;18(2):136-9. doi: 10.4103/0972-124X.131301.
Exploring the role of cranberry polyphenols in periodontits: A brief review.
Mukherjee M, Bandyopadhyay P, Kundu D.
These articles mainly concern periodontal pathogens in humans, but it has been shown that there is a similarity in the virulence and immunological characteristics between the periodontal parasites of humans and those of carnivorous animals.
Infect Immun. 2016 Aug 19;84(9):2575-85. doi: 10.1128/IAI.01500-15. Print 2016 Sep.
Porphyromonas gulae Has Virulence and Immunological Characteristics Similar to Those of the Human Periodontal Pathogen Porphyromonas gingivalis.
Lenzo JC, O’Brien-Simpson NM, Orth RK, Mitchell HL, Dashper SG, Reynolds EC.
Anaerobe. 2012 Aug;18(4):381-5. doi: 10.1016/j.anaerobe.2012.04.008. Epub 2012 May 17.
Occurrence and antimicrobial susceptibility of Porphyromonas spp. and Fusobacterium spp. in dogs with and
Senhorinho GN, Nakano V, Liu C, Song Y, Finegold SM, Avila-Campos MJ.
We are currently conducting further laboratory studies on bacteria causing halitosis (bad breath) and periodontal disease in dogs and cats. However, these results are not yet published.